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We have previously demonstrated an increased nicotinamide:nicotinic acid ratio in the adipose tissues of 5A-1MQ-treated DIO mice 13

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While B12 is generally safe, caution is needed in specific clinical situations: Lebers Disease (Hereditary Optic Neuropathy): B12 injections are generally contraindicated or should be used with extreme caution, as they may potentially aggravate optic atrophy in this rare condition

Another study found that AOD-9604 can promote the regeneration of cartilage tissue in vitro